Abraxane Drug Interactions

When rifamycin antibiotics, "live" vaccinations, or certain anticonvulsants are taken together with Abraxane, drug interactions may occur. Abraxane interactions may affect the level of Abraxane in your blood, which can increase your risk of developing side effects or decrease the effectiveness of the medicine.

 

Abraxane Drug Interactions: An Overview

Abraxane® (protein-bound paclitaxel) can potentially interact with other medications. Some of these medicines that may lead to Abraxane interactions include:
 
  • Certain antibiotics or antifungals, including:
o Clarithromycin (Biaxin®)
o Erythromycin (Ery-Tab®)
o Isoniazid (Nydrazid®)
o Itraconazole (Sporanox®)
o Ketoconazole (Nizoral®)
o Miconazole
o Telithromycin (Ketek®)
  • Certain anticonvulsants, including:
o Carbamazepine (Epitol®, Equetro™, Tegretol®, Tegretol XR®)
o Fosphenytoin (Cerebyx®)
o Phenobarbital (Luminal®)
o Pentobarbital (Nembutal®)
  • "Live" vaccinations, including:
o Chickenpox vaccine (varicella vaccine)
o FluMist® (the nasal vaccine for influenza; the injected vaccine is not live)
o MMR vaccine (measles, mumps, rubella vaccine)
o Smallpox vaccine
o BCG vaccine (used in some countries for tuberculosis)
  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®).
     
(Abraxane Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;