Aredia and Pregnancy

Since Aredia can cause low blood calcium, which can prolong labor and delivery, it is generally recommended that pregnant women avoid taking the drug. In clinical studies on Aredia and pregnancy, the medicine also caused bone changes in the offspring when it was given to pregnant rats. Due to these potential risks, alert your healthcare provider immediately if you are taking Aredia and pregnancy occurs.

Aredia and Pregnancy: An Overview

Aredia® (pamidronate disodium) is a prescription medication used to treat Paget's disease or bone problems in people with cancer. The manufacturer of Aredia warns that pregnant women should not take this medication. Studies in pregnant animals have suggested that Aredia may cause problems when used during pregnancy.
 

Aredia and Pregnancy Category D

The U.S. Food and Drug Administration (FDA) uses a pregnancy category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy Category D is a classification given to medicines that have been shown to present a risk to the fetus in studies of pregnant women but may still offer benefits that outweigh the risks that the drug presents. A pregnancy Category D medicine may still be given to a pregnant woman if the healthcare provider believes that the benefits to the woman outweigh the possible risks to the unborn child.
 
Even though Aredia has not been studied in pregnant women, it was still given a pregnancy Category D, due to the problems seen in animal studies. Aredia can cause low blood calcium, which can prolong labor and delivery. When given to pregnant rats, Aredia also caused bone changes in the offspring. Because Aredia is incorporated into bone and released from the bones very slowly, there is concern that Aredia might affect the developing bones of a fetus in humans.
 
In all but the rarest of circumstances, you should not take Aredia if you are pregnant or may become pregnant in the near future. If you are pregnant or thinking about becoming pregnant, let your healthcare provider know. He or she will consider both the benefits and risks of taking Aredia during pregnancy before making a recommendation for your particular situation.
 
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