Aredia Warnings and Precautions

Before taking Aredia, warnings and precautions for the medicine should be fully understood. Be sure to tell your healthcare provider if you have low blood calcium, kidney disease, or any allergies before starting the drug. Aredia can cause kidney damage, but you can reduce this risk by making sure that your dosage does not exceed 90 mg per dose and that you are receiving your dose over at least a two-hour period.

Aredia: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Aredia® (pamidronate disodium) if you have:
  • Kidney disease, including kidney failure (renal failure)
  • Low blood calcium (hypocalcemia)
  • Any allergies, including allergies to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding
  • Planning to have a dental procedure.
Make sure to tell your healthcare provider about all other medicines you may be taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings for Aredia

Warnings and precautions to be aware of prior to taking Aredia include the following:
  • Aredia can cause kidney damage. In order to decrease this risk, your Aredia dose should be given by IV over a period of at least two hours and should not exceed 90 mg per dose. Your healthcare provider should monitor your kidney function closely, using a simple blood test. If your kidney function is declining, you may need to postpone your dose until your kidney function improves. If you already have kidney disease, Aredia may not be a good choice for you.
  • In rare cases, bisphosphonates (such as Aredia) have caused a condition called osteonecrosis of the jaw. This is a serious, possibly disfiguring problem in which the bone of the jaw dies. Often, there are symptoms (such as pain, infection, or loosening of the teeth), but sometimes there are no symptoms until a person notices exposed bone. This problem is most common when bisphosphonates are given by IV. It seems that people who have dental procedures (such as a tooth extraction) are also at higher risk. Be sure to take good care of your mouth and teeth by seeing your dentist frequently. Let your healthcare provider know right away if you think you may have osteonecrosis of the jaw.
  • Aredia can cause low blood calcium, phosphate, and magnesium. Your healthcare provider should monitor you closely for these problems.
  • Bisphosphonates (including Aredia) can cause extreme muscle or bone pain. This usually goes away once the medication is stopped.
  • Aredia can potentially interact with a few other medications (see Aredia Drug Interactions).
  • Aredia is considered a pregnancy Category D medication. This means that it is probably not safe for use during pregnancy (see Aredia and Pregnancy).
  • It is not known whether Aredia passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Aredia and Breastfeeding).
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