Drug Interactions With Cyclophosphamide

Interactions With Cyclophosphamide Explained

The following sections explain in detail the potentially negative interactions that can occur when cyclophosphamide is combined with any of the drugs listed above.
 
Anthracyclines
Cyclophosphamide may increase the risk of heart problems due to anthracyclines. Your healthcare provider may need to carefully monitor your heart if you take these medications together.
 
Certain Anticonvulsants
Taking cyclophosphamide with certain anticonvulsants (seizure medications) can raise the level of cyclophosphamide in your blood, increasing your risk of cyclophosphamide side effects. If you are taking these medicines together, your healthcare provider may need to decrease your cyclophosphamide dosage.
 
Live Vaccinations
Because chemotherapy (including cyclophosphamide) can suppress the immune system, it is generally best to avoid live vaccinations while receiving chemotherapy.
 
Rifamycin Antibiotics
Taking cyclophosphamide with rifamycin antibiotics can raise the level of cyclophosphamide in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to decrease your cyclophosphamide dosage.
 

Final Thoughts on Drug Interactions With Cyclophosphamide

It is possible that not all cyclophosphamide drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific drug interactions with cyclophosphamide that may apply to you.
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