Faslodex is a hormone treatment for
breast cancer. It works in two ways. First, it works by binding to and blocking estrogen receptors. When Faslodex binds to an estrogen receptor, it blocks estrogen hormones from binding to that receptor. Essentially, the drug competes with the body's natural estrogen. However, unlike estrogen, Faslodex does not encourage breast cancer growth. Secondly, Faslodex decreases the amount of estrogen receptors on the cells, which also reduces the effect of estrogen on breast cancer.
Many breast cancers are sensitive to the estrogen hormone, meaning that the tumor grows with the help of estrogen. When a tumor is sensitive to estrogen, it has receptors on the outer surface of its cells, into which estrogen fits like a key opening a lock. When this connection is made, the cancer grows. Breast cancers that have estrogen (and/or progesterone) receptors are known as hormone receptor-positive tumors.
By decreasing the effects of estrogen, Faslodex can help decrease the growth of these breast cancers. This type of
breast cancer treatment is known as hormonal therapy.
Faslodex Uses in Children, Adolescents, and Men
Faslodex is not approved to treat breast cancer in children, adolescents, or men
(see Male Breast Cancer). Talk to your healthcare provider about the benefits and risks of using the drug in children or adolescents.
On occasion, your healthcare provider may recommend Faslodex for something other than the condition listed in this article. At this time,
off-label Faslodex uses include treating breast cancer in premenopausal women.
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