Femara Indications

Postmenopausal women who have certain types of breast cancer may be prescribed the drug Femara® (letrozole). The specific indications (or uses) for Femara include:
  • Early breast cancer that is hormone receptor-positive and the woman has had surgery
  • The woman has taken tamoxifen (Nolvadex®, Soltamox™) for five years after surgery or radiation for breast cancer
  • The woman has advanced or metastatic (spreading) breast cancer that is either hormone receptor-positive or hormone receptor-unknown.
Femara is not recommended for the treatment of breast cancer in children, adolescents, or men -- or for women who are premenopausal. However, it may be used in an off-label fashion for a couple of these groups.
This drug is a type of hormonal therapy, which means it works by blocking the enzymes that are responsible for the production of estrogen in the body. This, in turn, causes the growth of estrogen-sensitive breast cancers to slow down.
(To learn more about the possible indications for this drug, click Femara Uses. This article provides more information on how this medicine works and off-label uses, and provides a detailed explanation of breast cancer.)
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