Goserelin Acetate Implant Side Effects

Common Side Effects

The goserelin acetate implant has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people who received the goserelin acetate implant were carefully documented and compared to those that occurred in another group of people who received a different treatment or a placebo (an implant that did not contain any active ingredients). As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the other groups.
 
In these studies, common reactions to the goserelin acetate implant included:
 
  • Hot flushes -- in up to 96 percent of people
  • Headaches -- up to 75 percent
  • Vaginal irritation, itching, or discharge -- up to 75 percent
  • Decreased libido (sex drive) -- up to 61 percent
  • Mood changes -- up to 60 percent
  • Flushing (sudden redness of the face and neck) -- up to 57 percent
  • Sweating -- up to 45 percent
  • Acne -- up to 42 percent
  • Diarrhea -- up to 40 percent
  • Breast atrophy -- up to 33 percent
  • Flaky skin (dandruff) -- up to 26 percent
  • Fluid retention (edema) of the legs, ankles, and feet -- up to 21 percent
  • Decreased erections -- up to 18 percent.
 
Other common side effects, occurring in 1 to 18 percent of people, included but were not limited to:
 
  • Breast swelling, pain, or tenderness
  • Body pain, including pelvic, back, abdominal (stomach), muscle, and joint pain
  • Infections, such as urinary tract infections (UTIs) and respiratory tract infections
  • Pain during sexual intercourse
  • Urinary tract symptoms, such as feeling the need to urinate with urgency or more often than normal
  • Increased libido (sex drive)
  • Weakness and fatigue
  • Insomnia
  • Nausea and vomiting
  • Skin rash
  • Excessive or abnormal hair growth in women
  • Increased blood pressure (hypertension)
  • Increased or decreased appetite
  • Respiratory problems, such as coughing or breathing difficulty
  • Flu-like symptoms, including fever and chills
  • Dizziness
  • Injection site reactions
  • Hair loss (alopecia)
  • Nervousness
  • Painful menstrual periods
  • Constipation
  • Voice changes in women
  • Itching
  • Increased muscle tension
  • General feeling of discomfort
  • Dry mouth, eyes, or skin
  • Heartburn or indigestion
  • Bruising
  • Numbness, tingling, or pricking sensations of the skin
  • Drowsiness
  • Nosebleeds
  • Irregular or painful menstrual periods.
 
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Goserelin Acetate Implant Information

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