What Is Goserelin Acetate Implant Used For?

Using Goserelin Acetate Implants for Endometrial Thinning

Dysfunctional uterine bleeding (also called abnormal uterine bleeding) is a medical term that describes abnormal vaginal bleeding due to an imbalance in hormone levels. Women with this condition may experience heavy or longer-than-normal periods. They may also have bleeding or spotting between periods.
 
Endometrial ablation is a procedure that is used to treat dysfunctional uterine bleeding. It destroys a thin layer of the endometrium, which reduces or stops uterine bleeding. Unlike a hysterectomy, the uterus (or womb) is not removed during endometrial ablation. However, pregnancy is not likely after the procedure. Therefore, it is not recommended for women who wish to become pregnant.
 
Endometrial ablation works well in most cases. The lower strength of the goserelin acetate implant is approved to thin the lining of the uterus before an endometrial ablation. It may help improve the success rate of the procedure.
 

How Does It Work?

As mentioned, the goserelin acetate implant belongs to a group of medicines called gonadotropin-releasing hormone (GnRH) agonists. GnRH is a hormone found naturally in the body. It controls the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland (a tiny gland located beneath the brain). LH and FSH stimulate the production of testosterone in the testes and estrogen in the ovaries.
 
The goserelin acetate implant acts like GnRH, stimulating the production of LH and FSH. However, after several weeks, the implant overstimulates the pituitary gland and it stops making these hormones. As a result, levels of testosterone and estrogen decrease. This decrease  is responsible for the therapeutic effects of goserelin acetate implants.
 
This drug comes as a tiny implant that is injected beneath the skin of the abdomen (stomach). The implant slowly releases the medication as it dissolves over a period of 4 to 12 weeks (depending on the strength of the implant being used).
 
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Goserelin Acetate Implant Information

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