Halaven Warnings and Precautions

When determining whether Halaven is suitable for you, your healthcare provider needs to know about any other medical conditions you have, including kidney disease, liver disease, or low blood counts. Other warnings and precautions with Halaven involve possible drug interactions and allergic reactions. Also, make sure to tell your healthcare provider if you are pregnant or breastfeeding.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to receiving Halaven™ (eribulin mesylate) if you have:
 
  • Kidney disease, such as kidney failure (renal failure)
  • Liver disease, such as liver failure, hepatitis, or cirrhosis
  • Low blood counts
  • Long QT syndrome (a genetic irregular heart rhythm)
  • Low potassium or low magnesium levels
  • Any allergies, including allergies to foods, dyes, or preservatives.
 
Also, let your healthcare provider know if you are:
 
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
 
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
 

Specific Precautions and Warnings With Halaven

Some warnings and precautions to be aware of prior to receiving this medication include the following:
 
  • Halaven can decrease the bone marrow's ability to produce blood cells. This can result in anemia and other serious conditions. Because your immune system depends on certain blood cells, you may be more susceptible to infections while taking Halaven (see Chemotherapy and Infections). You will need regular blood tests to make sure your blood counts are not too low. These side effects can be quite serious.
 
  • Like most chemotherapy drugs, Halaven can cause severe nausea, vomiting, and diarrhea. Keep in close contact with your healthcare provider in order to anticipate, recognize, and treat these problems.
 
  • In studies, Halaven was shown to potentially cause a change in heart rhythm known as QT prolongation. This is a potentially serious change that can lead to life-threatening arrhythmias. Combining Halaven with other medications that have this potential probably increases the risk. If you must combine Halaven with other QT-prolonging medications, your healthcare provider should closely monitor your heart rhythm.
 
  • You will also need close heart rhythm monitoring if you are prone to low electrolytes (such as low blood potassium or low blood magnesium), as this increases the risk for problems due to QT prolongation. Additionally, people with congenital long QT syndrome should generally avoid using this medication.
 
  • Like several other chemotherapy medications, Halaven has a tendency to cause nerve problems. This may show up as nerve pain, unusual sensations (such as pricking or burning), or even problems with coordination or muscle control. Let your healthcare provider know right away if you suspect such problems.
 
  • If your liver or kidneys are not functioning properly, you may need a reduced Halaven dosage.
 
 
  • Halaven is considered a pregnancy Category D medication. This means that it is probably not safe for use during pregnancy. Talk to your healthcare provider about the risks and benefits of using the drug during pregnancy (see Halaven and Pregnancy).
 
  • It is not known if Halaven passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Halaven and Breastfeeding).
 
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