Herceptin Drug Interactions

When anthracyclines, mitoxantrone, or warfarin is taken with Herceptin, drug interactions can occur. These interactions can increase your risk of congestive heart failure or bleeding. Therefore, to prevent Herceptin drug interactions from occurring, talk to your healthcare provider before combining it with any medications.

 

An Overview of Herceptin Drug Interactions

Herceptin® (trastuzumab) can potentially interact with other medications. Some of these medicines that may lead to Herceptin drug interactions include:
 
  • Anthracyclines, including:
o Daunorubicin (Cerubidine®, DaunoXome®)
o Doxorubicin (Adriamycin®, Rubex®, Doxil®, Evacet®)
o Idarubicin (Idamycin®)
o Valrubicin (Valstar®) 
  • Mitoxantrone (Novantrone®)
  • Warfarin (Coumadin®, Jantoven®).
     

Herceptin Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Herceptin is combined with any of the drugs listed above.
 
Anthracyclines
Taking Herceptin and an anthracycline medication at the same time can increase your risk of congestive heart failure (CHF). These medications should not be taken together.
 
Mitoxantrone (Novantrone)
Taking Herceptin and mitoxantrone (which is very similar to anthracycline medications) at the same time can increase your risk of congestive heart failure (CHF). These medications should not be taken together.
(Herceptin Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;