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Serious Side Effects of Cyclophosphamide

Some side effects with cyclophosphamide are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Blood in the urine (which can be a sign of bladder damage)
  • Severe nausea, vomiting, or diarrhea
  • Blood in the stool
  • Decreased urination, which may be a sign of kidney damage
  • Difficulty breathing or water retention, which may be signs of congestive heart failure
  • Signs of an infection, such as chills or a fever (see Chemotherapy and Infections)
  • Severe mouth sores
  • Any unusual moles, skin sores that do not heal, or unusual lumps (which can be signs of new tumors or cancers)
  • Signs of an allergic reaction, including unexplained rash, hives, itching, and unexplained swelling.

Final Thoughts on Cyclophosphamide Side Effects

It is possible that you may experience some or none of the cyclophosphamide side effects listed in this article. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have side effects from a medicine that you have never tried. Therefore, make sure to let your healthcare provider know if you develop any side effects while taking cyclophosphamide or if something "just does not seem right." While it may not be a side effect, your healthcare provider will be able to diagnose and treat the problem.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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