Breast Cancer Home > Femara Warnings and Precautions

Among the conditions that you should let your healthcare provider know about before you take Femara are liver disease and any allergies you may have. Also, because Femara is likely to cause harm to a fetus during pregnancy, you should let your healthcare provider know (prior to taking Femara) if you are pregnant or thinking of becoming pregnant. Some other Femara warnings and precautions include potential drug interactions, the safety of taking Femara while nursing, and the risk of osteoporosis in some people who take this drug.

Femara: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Femara® (letrozole) if you have:
Also let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding
  • A premenopausal woman.


You should also make sure to tell your healthcare provider about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Femara Warnings and Precautions

Following are some warnings and precautions to be aware of prior to taking Femara:
  • The liver helps clear Femara from the body. Therefore, if you have liver disease, talk with your healthcare provider before taking the drug. Depending on the severity of your condition, your healthcare provider may recommend adjusting your Femara dosage or not taking the drug at all.
  • Femara (as well as most medications that decrease the effects of estrogens) can lead to osteoporosis. If you already have osteoporosis (or are at risk for the condition), your healthcare provider may recommend certain lifestyle changes or medication to protect you from fractures (see Osteoporosis Prevention).
  • Femara can potentially interact with certain other medications (see Femara Drug Interactions).
  • Femara is considered a pregnancy Category X medication. This means that it is likely to cause harm to a fetus during pregnancy. Talk with your healthcare provider about the risks and benefits of taking the drug while pregnant (see Femara and Pregnancy).
  • It is not known if Femara passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, discuss this with your healthcare provider prior to taking Femara (see Femara and Breastfeeding).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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