Breast Cancer Home > Herceptin

Herceptin is a prescription medication used to treat certain types of breast cancer and stomach cancer. You can receive your Herceptin dose intravenously every seven days at your healthcare provider's office, a hospital, or an infusion center. Potential side effects include diarrhea, nausea, and fatigue.

What Is Herceptin?

Herceptin® (trastuzumab) is a prescription medication used to treat breast cancer and stomach cancer (gastric cancer).
 
(Click Herceptin Uses for more information on what the drug is used for, including possible off-label uses.)
 

Who Makes Herceptin?

It is made by Genentech, Inc.
 

How Does It Work?

Herceptin is part of a group of medications called monoclonal antibodies. Monoclonal antibodies are used to treat a wide variety of conditions, including cancer. Herceptin is a special type of monoclonal antibody that is designed to bind to HER2, a protein on the outside of certain cancer cells. When Herceptin binds to HER2 receptor proteins, it has several effects. It may interfere with the cancer cells' ability to grow and multiply. By binding to the HER2 receptor, the drug may also serve as a signal to the immune system, which can help destroy the cancer cells.
 
Herceptin is not a form of chemotherapy. It is a biologic therapy, also known as biological therapy (see Biological Therapy for Breast Cancer). It is less "toxic" than chemotherapy, as it specifically targets the HER2 receptors. Because it is only used to treat cancers that have a high concentration of HER2 receptors, it targets the tumors, having less of an effect on healthy, noncancerous cells.
 
Before the medication can be prescribed for a particular patient, certain tests must be performed to make sure that the tumor "overexpresses" HER2. When a cell makes a certain receptor or protein, it is said to "express" that receptor or protein. Tumor cells that overexpress HER2 have a high concentration of the HER2 receptor. Not all cancers overexpress HER2, and not all people with breast or stomach cancer will benefit from Herceptin.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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