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Dosing Regimens for Perjeta

For treating metastatic breast cancer, Perjeta may be continued indefinitely, usually until either it stops working or side effects become a problem. When using the drug for neoadjuvant treatment (before surgery to shrink the tumor size) in people with early, inflammatory, or locally advanced breast cancer, one of the following regimens is recommended:
  • Four cycles of Perjeta plus docetaxel and trastuzumab before surgery, followed by three cycles of fluorouracil, epirubicin, and cyclophosphamide (FEC) after surgery
  • Three cycles of FEC, followed by three cycles of Perjeta plus docetaxel and trastuzumab, all before surgery
  • Six cycles of Perjeta plus docetaxel, trastuzumab, and carboplatin, all before surgery.
For all three regimens, trastuzumab should be continued after surgery to complete one year of treatment.

General Information on Receiving Perjeta

Some considerations to keep in mind during treatment with Perjeta include the following:
  • Sometimes, people develop reactions (known as "infusion reactions") while Perjeta is being administered by IV. In some cases, slowing the IV drip will help. In other cases, the IV may need to be stopped and other medications may need to be given in order to treat the reactions. These infusion reactions often include but are not limited to:
  • Most people receive their infusion at their healthcare provider's office, a hospital, or at an "infusion center."
  • For the medication to work properly, it must be used as prescribed. Perjeta will not work as well if you stop using it before your healthcare provider recommends.
  • If you are unsure about anything related to your dosage or Perjeta dosing in general, please talk to your healthcare provider or pharmacist.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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