Breast Cancer Home > Perjeta Drug Interactions

Combining Perjeta with anthracycline drugs, such as doxorubicin, epirubicin, or idarubicin, may cause negative interactions. In some cases, these combinations may increase the risk for heart problems, such as congestive heart failure. To minimize your risk for these and potentially other interactions, make sure your healthcare provider knows about any medications, vitamins, or supplements you are taking before starting treatment with Perjeta.

An Overview of Interactions With Perjeta

Perjeta™ (pertuzumab) can potentially react with a few other products. Some of the drugs that can lead to interactions with Perjeta include but are not limited to:
  • Anthracyclines, such as:

Perjeta Drug Interactions Explained

People who are taking an anthracycline medication or those who have ever taken an anthracycline in the past may have a higher risk for heart problems like congestive heart failure with Perjeta. The benefits of Perjeta must be weighed against the increased risks in these situations.
Would Perjeta interact with other medications besides anthracyclines? It does not appear that the possibility has been explored thoroughly. The prescribing information simply states that Perjeta does not interact with docetaxel (Taxotere®) or trastuzumab (Herceptin®), the two medications that are usually combined with Perjeta. No other interactions are specifically mentioned. It is possible that interactions may be discovered in the future.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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