If you have breast cancer or want to prevent it, you may benefit from tamoxifen citrate (Nolvadex®). This prescription medication is a type of selective estrogen receptor modulator (SERM) and works by binding to estrogen receptors in the breast. By decreasing the effects of estrogen, the drug can help decrease the growth of breast cancer.
In clinical studies, more women survived after 5 and 10 years on tamoxifen compared to those not taking the drug. Other studies have shown that tamoxifen can be beneficial in preventing breast cancer in women with ductal carcinoma in situ (DCIS) who have had surgery and radiation. Also, tamoxifen can help prevent breast cancer in women who are at high risk for the disease. In studies, the drug reduced the risk of developing breast cancer by as much as 44 percent.
(Click Tamoxifen to learn more about this drug's benefits. This article also looks at how tamoxifen works, what it is used for, and possible side effects.)
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Nolvadex [package insert]. Wilmington, DE: AstraZeneca Pharmaceuticals;2006 March.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: Approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed May 3, 2007.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 7th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2005.
National Library of Medicine (US). Drugs and Lactation Database (LactMED). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT. Accessed May 3, 2007.
eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind.
Site users seeking medical advice about their specific situation should consult with their own physician. Click