Breast Cancer Home > Thioplex Dosage

Thioplex is a chemotherapy drug that is given as an injection into a vein or directly into a body cavity. The recommended Thioplex dosage will depend on how much you weigh, the reason you are using it, and other factors. Your healthcare provider will administer the injection every one to four weeks in a healthcare setting.


An Introduction to Dosing With Thioplex

The dose of Thioplex® (thiotepa) your healthcare provider recommends will vary, based on a number of factors, including:
  • Your weight and possibly your height
  • How the medication is being given
  • The type of cancer you have
  • How you respond to and tolerate it
  • Other medical conditions you may have.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

What Is the Recommended Thioplex Dosage?

The recommended Thioplex dose for intravenous (IV) injection (an injection into a vein) is usually 0.3 mg to 0.4 mg per kg body weight (0.14 mg to 0.18 mg per lb) every one to four weeks. The usual recommended dose for injection directly into a body cavity, such as the lining of the lungs, heart, or abdomen (stomach), is 0.6 mg to 0.8 mg per kg (0.27 mg to 0.36 mg per lb) every one to four weeks.
The recommended dosage of Thioplex for administration directly into the bladder for people with bladder cancer is 60 mg once a week for four weeks. The dose may be repeated for an additional four to eight weeks if needed. Giving the medication for longer than four weeks increases the risk for side effects.
In general, higher Thioplex doses are normally used initially. Because this medication decreases the number of blood cells in your body, your healthcare provider will use blood tests to check how much your blood cells have been affected by each dose. Your next dose will be adjusted based on the results of these blood tests.
It is important to keep in mind that the doses discussed here are general recommended amounts. The actual dose of Thioplex can vary considerably from person to person. For example, in some cases a healthcare provider may recommend an amount based on body surface area. Body surface area is normally calculated using your height and weight. Your healthcare provider will choose the best dosing regimen for you, based on your individual situation.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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