Breast Cancer Home > Thioplex

If you have certain types of cancer, your healthcare provider may prescribe Thioplex. This medication is approved to treat a number of cancers, such as bladder cancer, ovarian cancer, breast cancer, and lymphoma. It is given as an injection into a vein or directly into the body cavity once every one to four weeks. Side effects include fatigue, nausea, and vomiting.


What Is Thioplex?

Thioplex® (thiotepa) is a prescription medication approved for the treatment of a variety of types of cancer, such as bladder cancer, breast cancer, cancer of the ovaries, and lymphoma (cancer of the immune system). It is also used to control the abnormal accumulation of fluid in body cavities (known medically as effusion) that may result from certain cancers.
Thioplex belongs to a group of chemotherapy medicines known as alkylating agents. It may also be referred to by the names triethylenethiophosphoramide, TSPA, or TESPA.
(Click Thioplex Uses for more information on this topic, including possible off-label uses.)

Who Makes This Medication?

Thioplex was previously made by Immunex. However, Immunex no longer makes brand-name Thioplex. Currently, this medication is only available in generic form. Generic thiotepa is made by Bedford Laboratories.

How Does Thioplex Work?

Thioplex is part of a group of medications called alkylating agents. Alkylating agents are medications that transfer a piece of their structure, called an alkyl group, to DNA. This causes the strands of DNA to bond to each other and become linked (known as "cross-linking"). The linked strands are unable to uncoil and separate, which is necessary for the DNA to replicate.
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Last reviewed by: Kristi Monson, PharmD;
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