Breast Cancer Home > Tykerb Dosage

When treating breast cancer, most people take a Tykerb dosage of 1250 mg or 1500 mg a day, depending on which medication it is being taken with. A lower amount is recommended for people with severe liver disease or who are taking drugs that increase the level of Tykerb in the blood.

Tykerb Dosage: An Introduction

The dose of Tykerb® (lapatinib) that your healthcare provider recommends will vary, depending on a number of factors, including:
  • Other medications you may be taking
  • Other medical conditions you may have.
As is always the case, do not adjust your Tykerb dose unless your healthcare provider specifically instructs you to do so.

Tykerb Dosage in Combination With Xeloda

The usual recommended dose of Tykerb in combination with Xeloda® (capecitabine) for breast cancer treatment is 1250 mg (five tablets), taken once daily at least one hour before or one hour after a meal. Tykerb is taken every day for a 21-day cycle, and Xeloda is taken only on days 1 to 14 of that cycle. After 21 days, the cycle is started over with no days in between. Essentially, Tykerb is taken every single day, but Xeloda is taken for two-week periods with one week in between.
Tykerb (along with Xeloda) is usually taken until the cancer becomes worse or until dangerous or bothersome Tykerb side effects occur.

Tykerb Dosage in Combination with Femara

The usual recommended dose of Tykerb in combination with Femara® (letrozole) for breast cancer treatment is 1500 mg (six tablets, all at once), taken once daily at least one hour before or one hour after a meal. The usual dosage of Femara when used in combination with Tykerb is 2.5 mg once daily. These two medications are used continuously, not in cycles.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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