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Serious Xeloda Side Effects

Some side effects with Xeloda, while occurring infrequently, are potentially serious and should be reported immediately to your healthcare provider. These include, but are not limited to:
  • Depression (see Xeloda and Depression)
  • Signs of a blood clot, such as pain, swelling, or tenderness (especially in the legs)
  • Blood in the stool or coughing up blood (signs of gastrointestinal bleeding)
  • Very severe constipation, nausea, vomiting, or mouth sores
  • Severe pain or redness of the hands or feet
  • An increase in tumor size or appearance of new tumors
  • A fever or other signs of an infection (see Chemotherapy and Infections)
  • Signs of liver problems, such as yellowing of the whites of the eyes or skin, dark urine, and right upper abdominal (or stomach) pain.
  • Signs of an allergic reaction, including an unexplained rash, hives, itching, and unexplained swelling.

Less Common Problems

Less common side effects of Xeloda occur in less than 5 percent of people taking the drug. Because these side effects are so uncommon, it can be difficult to tell whether they are actually caused by Xeloda or by factors unrelated to the medication.
Some of these rare side effects include, but are not limited to:
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Last reviewed by: Kristi Monson, PharmD;
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