Perjeta is administered intravenously by a healthcare provider every three weeks. Regardless of your age, weight, or other factors, the Perjeta dosage is standard for everyone. The first dose is 840 mg and the subsequent doses are 420 mg. Let your healthcare provider know immediately if you develop fever, chills, or other signs of an infusion reaction while receiving Perjeta.
An Introduction to Dosing With PerjetaUnlike the vast majority of medications used to treat cancer, there is only one standard dosage of Perjeta™ (pertuzumab), regardless of your age, weight, or any other factors. As is always the case, do not adjust your Perjeta dosage unless your healthcare provider specifically tells you to do so.
What Is the Recommended Perjeta Dosage?The first dose of Perjeta is 840 mg (two vials) given intravenously (by IV) over 60 minutes. After that first dose, the standard dosing regimen is 420 mg of Perjeta (one vial) given over 30 to 60 minutes by IV, every three weeks.
Perjeta is meant to be used along with docetaxel (Taxotere®) and trastuzumab (Herceptin®), two other breast cancer medications. If, for whatever reason, you must stop taking trastuzumab, it is recommended that you also stop using Perjeta; Perjeta is more effective when used in combination with trastuzumab. However, if you must stop taking docetaxel, you may continue to take trastuzumab and Perjeta.
Perjeta sometimes affects the heart and, in severe cases, can cause heart failure. Your heart will be monitored closely. If you develop heart problems, your infusion may need to be delayed or you may need to stop using the drug altogether.
If you miss or delay a dose of Perjeta, you can continue with the 420-mg dosage as long as it has been six weeks or less since the last dose. If it has been longer than six weeks, you should restart with the higher (840 mg) one-time dosage.