Drug Interactions With Tamoxifen

More Information on Interactions With Tamoxifen

The following sections explain in detail the potentially negative interactions that can occur when tamoxifen is combined with any of the drugs listed above.
 
Aminoglutethimide
Taking tamoxifen with aminoglutethimide may decrease the level of tamoxifen in your blood, perhaps making it less effective. Your healthcare provider may need to increase your tamoxifen dose to prevent this interaction from occurring.
 
Anastrozole
Tamoxifen can decrease the level of anastrozole in your blood, perhaps making it less effective. The manufacturer of tamoxifen states that these two medications should not be taken together.
 
Bromocriptine
Bromocriptine can increase the level of tamoxifen in your blood, increasing your risk for tamoxifen side effects. Your healthcare provider may need to decrease your dose of tamoxifen to prevent this drug interaction from occurring.
 
Certain Anticonvulsants
Taking tamoxifen with certain anticonvulsants may decrease the level of tamoxifen in your blood, perhaps making it less effective. Your healthcare provider may need to increase your tamoxifen dosage to prevent this.
 
Chemotherapy Medications
Combining tamoxifen with chemotherapy medications may increase the risk of blood clots. Talk to your healthcare provider about the risks and benefits of combining these medications in your particular situation.
 
Estrogens
Estrogens may decrease the effectiveness of tamoxifen. Therefore, estrogens should not be taken with this drug.
 
Letrozole
Tamoxifen can decrease the level of letrozole in your blood, perhaps making it less effective. Your healthcare provider may need to increase your letrozole dosage to prevent this drug interaction from occurring.
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