Tamoxifen and Weight Gain

Side effects are possible with tamoxifen, and weight gain has been reported by some people taking the drug, although weight loss appears to be more common. Tips for combating weight gain include eating a heart-healthy diet and getting at least 30 minutes of exercise a day. If you are taking tamoxifen and weight gain continues to be a problem, your healthcare provider may recommend another breast cancer medication.

 

Tamoxifen and Weight Gain: An Overview

Weight gain is a common complaint in people taking tamoxifen citrate (Nolvadex®, Soltamox™). The side effect occurs in up to 9 percent of people taking the drug. However, even more people (up to 23 percent) reported experiencing weight loss with tamoxifen.
 

Tamoxifen and Weight Gain: Suggestions

If you are noticing an unexplained weight gain with tamoxifen, there are some things that you can do. Suggestions include:
 
  • Eat a heart-healthy diet. This diet should include foods such as:
     
    • Lots of fruits, vegetables, grains, and fat-free or low-fat milk and milk products
    • Lean meats, poultry, fish, beans, eggs, and nuts.
 
  • Limit foods with saturated fats, trans fats, cholesterol, sodium (salt), and added sugars.
     
  • Get regular physical activity for at least 30 minutes a day on most days of the week.
     
  • Limit your intake of alcohol.
     
(Click BMI Calculator to see if your weight is within a healthy range.)
 

Tamoxifen and Weight Gain: Final Thoughts

If you are taking tamoxifen and weight gain occurs, talk to your healthcare provider. He or she can give you other suggestions for dealing with any weight gain. If the weight gain continues, he or she may recommend adjusting the tamoxifen dosage or switching to another breast cancer medication.
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;