Taxotere Drug Interactions

When medications such as certain antibiotics and some seizure medications are taken together with Taxotere, drug interactions may occur. Some of these drug interactions with Taxotere can alter the level of Taxotere in your blood, potentially increasing your risk of side effects or decreasing the effectiveness of the medication. To avoid these drug interactions, be sure to talk to your healthcare provider prior to taking Taxotere about specific interactions that may apply to you.

An Overview of Taxotere Drug Interactions

Taxotere® (docetaxel) can potentially interact with other medications. Some of these medicines that may lead to Taxotere interactions include:
 
  • Certain antibiotics or antifungals, including:
o Erythromycin (Ery-Tab®)
o Isoniazid (Nydrazid®)
o Itraconazole (Sporanox®)
o Ketoconazole (Nizoral®)
o Miconazole
o Telithromycin (Ketek®) 
  • Certain anticonvulsants, including:
o Carbamazepine (Epitol®, Equetro™, Tegretol®, Tegretol XR®)
o Fosphenytoin (Cerebyx®)
o Phenobarbital (Luminal®)
o Pentobarbital (Nembutal®)
  • Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
  • "Live" vaccinations, including:
o FluMist® (the nasal vaccine for influenza; the injected vaccine is not live)
o MMR vaccine (measles, mumps, rubella vaccine)
o Smallpox vaccine
o BCG vaccine (used in some countries for tuberculosis) 
  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®).
     

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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