Thioplex Drug Interactions

Thioplex Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Thioplex is combined with any of the drugs listed above.
 
Amphotericin B
Combining amphotericin B with chemotherapy medicines, including Thioplex, may increase the risk for amphotericin B side effects, such as kidney damage, low blood pressure (hypotension), and lung problems. Your healthcare provider may choose to monitor you more closely if you use these medicines together.
 
Bupropion
Thioplex may increase blood levels of bupropion, potentially increasing the risk for bupropion side effects. Talk to your healthcare provider about this potential interaction if you take this drug during Thioplex treatment.
 
Biologic and Immunologic Medications
Using Thioplex in combination with certain biologic and immunologic medications could increase your risk for potentially serious side effects, including infections and anemia. Thioplex should not be used in combination with some of these medications, while other combinations require careful monitoring. Talk to your healthcare provider about this potential interaction if you are taking a biologic or immunologic drug during chemotherapy treatment.
 
Clozapine
Using clozapine and Thioplex together may increase the risk for dangerously low white blood cells and potentially serious infections. Talk to your healthcare provider before using these medicines together. However, do not stop taking clozapine unless your healthcare provider specifically tells you to do so.
 
Cyclophosphamide
Thioplex may increase blood levels of cyclophosphamide, increasing the risk for cyclophosphamide side effects. Talk to your healthcare provider about this potential interaction if you use these medications together.
 
Echinacea
Echinacea may decrease the effectiveness of Thioplex. Do not take echinacea during Thioplex treatment without first speaking with your healthcare provider.
 
Efavirenz
Thioplex may increase blood levels of efavirenz, increasing the risk for efavirenz side effects. Talk to your healthcare provider about this potential interaction if you use these drugs together.
 
Irinotecan
Thioplex may increase blood levels of irinotecan, increasing the risk for irinotecan side effects. Talk to your healthcare provider about this potential interaction if you take this drug during Thioplex treatment.
 
Ketamine
Thioplex may increase blood levels of ketamine. Ketamine is generally used as a general anesthetic (a medication that causes you to be unconscious) before certain medical procedures. Make sure your healthcare provider knows you are using Thioplex if you will be receiving ketamine during chemotherapy treatment.
 
Live Vaccinations
Live vaccines contain live viruses or bacteria. If you receive a live vaccine during Thioplex treatment, you could become infected with the virus or bacteria used to make the vaccine. Also, live vaccines may be less effective in people receiving Thioplex. You should not receive a live vaccine during chemotherapy treatment.
 
Methadone
Thioplex may increase methadone blood levels, which could increase the risk for potentially serious methadone side effects. Talk to your healthcare provider about this potential interaction if you take drug during chemotherapy treatment.
 
Other Chemotherapy Alkylating Agents
In general, combining chemotherapy medicines that work in the same way may increase the risk for developing side effects, such as bone marrow depression (low blood cell counts). The manufacturer of Thioplex recommends that such drugs not be used together.
 
If you have been treated with another alkylating agent prior to using Thioplex, your healthcare provider will need to make sure your blood cell counts have recovered before starting Thioplex. Likewise, if you will be receiving another alkylating agent after Thioplex, your blood cell counts should be near normal before starting treatment with the other drug. 
 
Promethazine
Thioplex may increase promethazine blood levels, increasing the risk for promethazine side effects. Talk to your healthcare provider about this potential interaction if you use these drugs together. Your healthcare provider may give you a lower promethazine dosage.
 
Propofol
Thioplex may increase blood levels of propofol. Propofol is normally used to render people unconscious before certain medical procedures. Make sure your healthcare provider knows you are using Thioplex if you will be receiving propofol during chemotherapy treatment.
 
Roflumilast
Combining roflumilast with Thioplex may further increase your risk for developing infections. Talk to your healthcare provider about this potential interaction before using these medicines together.
 
Selegiline
Thioplex may increase selegiline blood levels, increasing the risk for selegiline side effects. Talk to your healthcare provider about this potential interaction if you use these medicines together. Your healthcare provider may need to adjust your selegiline dosage.
 
Sipuleucel-T
Thioplex may decrease the effectiveness of sipuleucel-T. This is because sipuleucel-T is thought to work by stimulating the body's immune system, while Thioplex decreases the activity of the immune system. Talk to your healthcare provider about this possible interaction before using these medicines together.
 
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