Tykerb Drug Interactions
The following sections explain in detail the potentially negative interactions that can occur when Tykerb is combined with any of the drugs listed above.
If you have had high doses of anthracyclines, taking Tykerb may increase your risk of heart problems, including heart failure or an irregular heart rhythm called QT prolongation. Your healthcare provider may need to monitor your heart closely if this is the case.
Certain Antibiotics or Antifungals
Certain antibiotics or antifungals can increase the level of Tykerb in your blood, potentially increasing your risk of Tykerb side effects. In addition, combining some antibiotics with Tykerb can increase the risk of a dangerous irregular heart rhythm called QT prolongation. Talk to your healthcare provider before taking Tykerb with any of these antibiotics or antifungal medications. Depending on the particular medication and your situation, your healthcare provider may recommend a decreased Tykerb dosage or suggest that you not take these medications together.
Certain Seizure Medications
Some seizure medications can greatly decrease the level of Tykerb in your blood, perhaps making it less effective. Talk to your healthcare provider before using Tykerb with seizure medications.
Medications That Prolong the QT Interval
Tykerb prolongs the QT interval, which means that it may increase the risk of a life-threatening irregular heart rhythm. In general, you should not take Tykerb with other medications that can also prolong the QT interval.
Nefazodone may increase the level of Tykerb in your blood, possibly increasing your risk of side effects. Your healthcare provider may suggest a lower Tykerb dose if you are taking these medications together.