Tykerb Drug Interactions

When medicines such as nefazodone or pioglitazone are taken with Tykerb, drug interactions may occur. If these interactions develop, your risk of developing side effects is increased and the level of Tykerb in your blood may be increased or decreased. Other medicines that can cause drug interactions with Tykerb include rifamycin antibiotics, anthracycline chemotherapy medications, and certain seizure medications.

Tykerb Drug Interactions: An Overview

Tykerb® (lapatinib) can potentially interact with other medications. Some of the medicines that may lead to Tykerb drug interactions include:
 
  • Anthracycline chemotherapy medications, such as:
o Daunorubicin (Cerubidine®, DaunoXome®)
o Doxorubicin (Adriamycin®, Doxil®)
o Idarubicin (Idamycin®)
o Mitoxantrone (Novantrone®)
o Valrubicin (Valstar®)
  • Certain antibiotics or antifungals, such as:
o Ciprofloxacin (Cipro®, Cipro XR®)
o Clarithromycin (Biaxin®, Biaxin XL®)
o Erythromycin (Ery-Tab®)
o Gemifloxacin (Factive®)
o Isoniazid (Nydrazid®)
o Itraconazole (Sporanox®)
o Ketoconazole (Nizoral®)
o Miconazole
o Mefloquine (Lariam®)
o Norfloxacin (Noroxin®)
o Ofloxacin (Floxin®)
o Telithromycin (Ketek®)
o Troleandomycin (Tao®)
  • Certain seizure medications, such as:
o Carbamazepine (Carbatrol®, Epitol®, Equetro™, Tegretol®, Tegretol XR®)
o Fosphenytoin (Cerebyx®)
o Phenobarbital (Luminal®)
o Pentobarbital (Nembutal®)
  • Medications that cause an irregular heart rhythm called QT prolongation (see QT Prolonging Medications for a more detailed list), including:
o Chloroquine (Aralen®)
o Certain anesthetics
o Certain antibiotics
o Certain arrhythmia medications
o Certain cancer medications
o Certain nausea and vomiting medications
o Certain phenothiazine or antipsychotic medications
o Cisapride (Propulsid®)
o Cyclobenzaprine (Flexeril®, Fexmid™)
o Methadone (Dolophine®)
o Octreotide (Sandostatin®)
o Pentamidine (NebuPent®, Pentam®)
o Ranolazine (Ranexa®)
o Tacrolimus (Prograf®)
 
 
 
  • Protease inhibitors, such as:
 
  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®)
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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