Xeloda Drug Interactions

When leucovorin, phenytoin, or warfarin is taken with Xeloda, drug interactions may occur. These interactions can increase your risk for certain side effects or may cause bleeding. Your healthcare provider may closely monitor the levels of these medications in your blood and adjust the doses as necessary. It is important to talk to your healthcare provider about specific drug interactions with Xeloda that may apply to you.

 

An Overview of Xeloda Drug Interactions

Xeloda® (capecitabine) can potentially interact with other medications. Some of these medicines that may lead to Xeloda interactions include:
 

Xeloda Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Xeloda is combined with any of the drugs listed above.
 
Leucovorin
Taking Xeloda with leucovorin can increase your risk of side effects. In general, these medications should not be taken together.
 
Phenytoin (Dilantin, Phenytek)
Xeloda can increase the level of phenytoin in your blood, increasing the risk of phenytoin side effects. Your healthcare provider should closely monitor the level of phenytoin in your blood and adjust your phenytoin dosage as necessary.
 
Warfarin (Coumadin, Jantoven)
Taking Xeloda with warfarin can increase your risk of bleeding. Your healthcare provider should monitor you frequently and adjust your warfarin dosage as necessary.
 

Final Thoughts on Xeloda Drug Interactions

It is possible that not all Xeloda drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific drug interactions with Xeloda that may apply to you.
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;