Commonly reported Xeloda side effects include anemia, diarrhea, and nausea. These side effects are typically minor, however, and easily treated. Serious side effects of Xeloda, while less common, should be reported immediately to your healthcare provider. These side effects include signs of an allergic reaction, an increase in tumor size, signs of a blood clot, and depression.

• Anemia -- in up to 80 percent of people (see Chemotherapy and Anemia)
• Hand-and-foot syndrome (redness and tenderness of the palms and soles) -- up to 60 percent
• Diarrhea -- up to 55 percent (see Chemotherapy-Induced Diarrhea)
• Nausea -- up to 53 percent (see Chemotherapy and Nausea)
• Fatigue or weakness -- up to 42 percent (see Chemotherapy and Fatigue)
• Vomiting -- up to 37 percent
• Abdominal pain (stomach pain) -- up to 35 percent
• Loss of appetite -- up to 26 percent
• Neutropenia (low levels of a certain type of white blood cell) -- up to 26 percent
• Mouth sores -- up to 25 percent (see Mouth and Gum Problems During Chemotherapy)
• Unusual sensations (such as burning or tingling) in the hands or feet -- up to 21 percent (see Nerve and Muscle Problems During Chemotherapy).
   

• Constipation (see Constipation With Chemotherapy)
• Eye irritation, vision changes, or conjunctivitis ("pink eye")
• Difficulty breathing
• Pain, including back pain, muscle pain, or joint pain (see Chemotherapy-Related Pain)
• Lethargy
• Headaches
• Indigestion or heartburn
• Dizziness
• Insomnia (see Xeloda and Insomnia)
• Dehydration
• Coughing
• Hair loss (see Xeloda and Hair Loss)
• Taste changes
• Mood changes.