Drug Interactions With Zoledronic Acid

Zoledronic Acid Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when zoledronic acid is combined with any of the drugs listed above.
 
Aminoglycosides
Taking zoledronic acid with an aminoglycoside antibiotic can increase the risk of low blood calcium (hypocalcemia) and kidney damage. Talk to your healthcare provider before taking these medications together.
 
Diuretics
Combining zoledronic acid with a diuretic may increase the risk of kidney damage. It is very important that you are adequately hydrated before your zoledronic acid dose, particularly if you are taking a diuretic. If you are not adequately hydrated, your healthcare provider may need to give you IV fluids before your dose. Also, some diuretics (but not all) can increase the risk of low blood calcium with zoledronic acid. Talk with your healthcare provider before taking zoledronic acid with a diuretic.
 
Nonsteroidal Anti-Inflammatory Drugs (NSAIDS)
Combining an NSAID with zoledronic acid may increase the risk of kidney damage, particularly in people who already have kidney disease. Talk with your healthcare provider before combining zoledronic acid with an NSAID.
 
Teriparatide (Forteo)
In studies, combining teriparatide with medications like zoledronic acid seemed to make teriparatide less effective. Talk to your healthcare provider before using these medications together.
 
Vancomycin (Vancocin)
Taking zoledronic acid with vancomycin can increase your risk of kidney damage. Talk with your healthcare provider before taking these medications together, particularly if you already have kidney disease.
 
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