Side Effects of Zoledronic Acid

Common Side Effects of Zoledronic Acid

Zoledronic acid has been studied thoroughly in clinical trials, in which a group of people taking the drug have side effects documented and compared to another group not taking the medicine. This way, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine.
 
In these studies, the most common side effects of the Zometa brand of zoledronic acid included:
 
  • Nausea -- in up to 46 percent of people
  • Fever -- up to 44.2 percent
  • Fatigue -- up to 39 percent
  • Anemia -- up to 33 percent
  • Vomiting -- up to 32 percent
  • Constipation -- up to 31 percent
  • Diarrhea -- up to 24 percent
  • Muscle pain -- up to 23 percent
  • Cough -- up to 22 percent
  • Joint pain -- up to 21 percent.
     
Common side effects of the other brand of zoledronic acid (Reclast) included:
 
  • Joint pain -- in up to 23.8 percent of people
  • Fever -- up to 17.9 percent
  • High blood pressure (hypertension) -- up to 12.7 percent
  • Headaches -- up to 12.4 percent
  • Muscle pain -- up to 11.7 percent
  • Extremity pain -- up to 11.3 percent
  • Flu-like symptoms (such as fever, fatigue, and chills) -- up to 11 percent.
      
(Click Reclast Side Effects and Zometa Side Effects for more information about the specific side effects of each individual drug.)
  

Final Thoughts on Side Effects of Zoledronic Acid

You may experience some or none of the zoledronic acid side effects listed in this article. Unfortunately, there is no way for your healthcare provider to know beforehand whether you will have side effects from a medicine that you have never tried. Therefore, make sure to let your healthcare provider know if you develop any side effects while taking the drug or if something "just does not seem right." While it may not be a side effect of zoledronic acid, your healthcare provider will be able to diagnose and treat the problem.
 
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