Side Effects of Zoledronic Acid

Constipation, fatigue, and fever are some of the most common side effects of zoledronic acid (Zometa brand). The most common side effects of the Reclast brand of zoledronic acid include headache, dizziness, and nausea. There are also some potentially serious zoledronic acid side effects that should be reported to a healthcare provider, including severe bone or muscle pain, jaw or tooth problems, and decreased urination.

Side Effects of Zoledronic Acid: An Introduction

As with any medicine, side effects are possible with zoledronic acid (Reclast®, Zometa®); however, not everyone who takes the medication will experience side effects. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with zoledronic acid. Your healthcare provider can discuss a more complete list of side effects with you.)

Serious Zoledronic Acid Side Effects

Some side effects with zoledronic acid, while occurring infrequently, are potentially serious and should be reported immediately to your healthcare provider. These include, but are not limited to:
  • Low blood levels of calcium (hypocalcemia), phosphate (hypophosphatemia), and magnesium (hypomagnesemia)
  • Decreased urination (which may be a sign of kidney damage)
  • Severe bone, muscle, or joint pain
  • Jaw or tooth problems
  • A rapid and irregular heart rhythm
  • Groin or thigh pain, as these might be symptoms of a rare type of broken bone that has been reported with medications like zoledronic acid 
  • Signs of an allergic reaction, including unexplained rash, hives, itching, unexplained swelling, wheezing, or difficulty breathing.


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