Zoledronic Acid Dosing

Zoledronic Acid Dosage for High Blood Calcium

The recommended zoledronic acid dose for treating high blood calcium due to cancer (known medically as hypercalcemia of malignancy) is 4 mg as a single dose. However, your healthcare provider may recommend a lower zoledronic acid dose if you have decreased kidney function. Your healthcare provider should check your kidney function (using a simple blood test) before your zoledronic acid dose. If necessary, you may need to be retreated with zoledronic acid if you do not fully respond to the medication (if your blood calcium does not return to normal). In this case, there should be at least seven days between doses.
 
Zometa (not Reclast) is the form of zoledronic acid that should be taken for this use.
 

Zoledronic Acid Dosage for Preventing Bone Problems

Zoledronic acid is also used to prevent bone problems (such as broken bones) in people with cancer. For this use, the recommended dose is zoledronic acid 4 mg every three to four weeks. Your healthcare provider should measure your kidney function (using a simple blood test) before each dose and should adjust your dose as necessary. People with decreased kidney function need lower dosages.
 
Zometa (not Reclast) is the form of zoledronic acid that should be taken for this use.
 

Zoledronic Acid Dosage for Osteoporosis

The recommended dose of zoledronic acid for treating osteoporosis in men and postmenopausal women is 5 mg per year, which is injected as a single dose using an IV. It should take at least 15 minutes to inject the dose. The same dosage is also recommended for preventing or treating osteoporosis due to glucocorticoid steroid medications.
 
You should take calcium (at least 1200 mg a day) and vitamin D (800 to 1000 IU daily) after your zoledronic acid dose. Calcium and vitamin D are important for Reclast to work properly and are also important to help prevent low blood calcium (one of the possible side effects). This is especially important in the two weeks after your dose.
 
Reclast (not Zometa) is approved for osteoporosis treatment.
 
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Zoledronic Acid for Cancer

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