Zoledronic Acid

Effects of Zoledronic Acid

Zoledronic acid has been examined in several studies for various conditions.
High Blood Calcium
Two studies compared zoledronic acid with pamidronate (Aredia®), another bisphosphonate, for the treatment of high blood calcium due to cancer. About ten days after the injection, 88 percent of people who took zoledronic acid had normal calcium levels, compared to 70 percent of those who took Aredia.
Bone Cancer
Zoledronic acid has also been studied for preventing broken bones and other bone problems in people with cancer that affects the bone. These studies measured the occurrence of indicators of bone problems, such as broken bones, bone surgery, bone radiation therapy, and spinal cord compression (pressure on the spinal cord caused by spinal fractures or other problems). People who took zoledronic acid had fewer of these problems, compared to those who did not take it. The medication also delayed the development of these bone problems.
Paget's Disease
One way to assess the severity of Paget's disease is by measuring the level of alkaline phosphate in the blood. In studies, zoledronic acid was shown to decrease alkaline phosphate levels, which indicates that it helps to improve Paget's disease. Studies compared a single dose of zoledronic acid with daily Actonel® (risedronate) 30 mg, a similar medication used to treat Paget's disease. Up to 89 percent of people who took zoledronic acid achieved normal alkaline phosphate levels, compared to just 58 percent of those taking Actonel. Additionally, zoledronic acid seemed to work more quickly than Actonel.
Zoledronic acid has also been studied as a treatment for osteoporosis in postmenopausal women. Studies showed that one dose per year reduces the risk of vertebral (spine) fractures, hip fractures, and fractures in general, compared to a placebo injection (an injection with no active ingredient). Both groups of women were also given vitamin D and calcium supplements. These studies showed that zoledronic acid can prevent the loss of height that can occur in people with osteoporosis.
Additionally, studies have shown that zoledronic acid can increase bone mineral density in men with osteoporosis. Also, one study compared zoledronic acid yearly injections with oral bisphosphonate medication for treating and preventing osteoporosis due to glucocorticoid steroids (such as prednisone). This study showed that zoledronic acid was superior for increasing bone mineral density.
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