Zoledronic Acid

When and How to Take Zoledronic Acid

General considerations for when and how to take zoledronic acid include the following:
  • The medication comes in injectable form. Your healthcare provider will give it by IV, usually at a hospital or clinic. Zoledronic acid should be given over a period of at least 15 minutes (giving it too quickly increases the risk of kidney problems).
  • For high blood calcium or Paget's disease, zoledronic acid is given as a single dose (although in some situations, retreatment may be necessary).
  • For preventing bone problems due to multiple myeloma or solid tumors, zoledronic acid is given once every three to four weeks. For osteoporosis, it is given once a year.
  • It is important that you get enough calcium and vitamin D while taking zoledronic acid.
  • It is very important that you are well hydrated before receiving your zoledronic acid dose in order to protect your kidneys. Make sure to drink enough fluids in the days before you receive the medication. In many cases, your healthcare provider may need to give you IV fluids to make sure you are hydrated enough.

Dosing Information

The dose of zoledronic acid your healthcare provider recommends will vary, depending on a number of factors, including:
  • Which product is used (Reclast or Zometa)
  • How well your kidneys are functioning
  • The condition being treated
  • Other medications you may be taking
  • Other medical conditions you may have.
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
(Click Zoledronic Acid Dosing for more information.)
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